📋Overview
Alexander disease is a rare, progressive neurological disorder classified as a leukodystrophy, primarily affecting the white matter of the brain. It is caused by mutations in the GFAP gene, leading to abnormal accumulation of Rosenthal fibers in astrocytes. The condition is named after the neurologist who first described it but is now recognized by its genetic and pathological basis. It mainly affects the central nervous system and presents with varying symptoms depending on the age of onset.
Medical codes (for reference)
UMLS CUI: C0270726ICD-10-CM
G31.86
MeSH
D038261
SNOMED CT (US)
81854007
Codes are provided for reference and interoperability. They are not a diagnosis.
Found an Error?
Help us keep this information accurate. If you notice any incorrect details, please submit a correction request.