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Alobar Holoprosencephaly - Medical Condition Information

Alobar Holoprosencephaly

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Alobar holoprosencephaly is the most severe form of holoprosencephaly, a congenital brain malformation characterized by incomplete division of the embryonic forebrain (prosencephalon) into two hemispheres. It is a developmental disorder resulting in a single, undivided cerebral hemisphere and severe brain and facial abnormalities. Holoprosencephaly is classified into alobar, semilobar, and lobar types based on the degree of brain division, with alobar being the most severe and incompatible with normal brain function.

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