Chronic Myeloid Leukemia
CML
📋Overview
Chronic Myeloid Leukemia (CML) is a type of blood cancer characterized by the uncontrolled growth of myeloid cells in the bone marrow and their accumulation in the blood. It is defined by the presence of the Philadelphia chromosome, a genetic abnormality resulting from a translocation between chromosomes 9 and 22, which creates the BCR-ABL1 fusion gene. This gene produces an abnormal tyrosine kinase protein that drives the proliferation of leukemic cells. CML typically progresses through three phases: chronic, accelerated, and blast crisis. Modern treatment focuses on targeted therapies that inhibit the BCR-ABL1 tyrosine kinase.
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